Baricent is indicated for the treatment of moderate to severely active Rheumatoid Arthritis in adult patients who have had an inadequate response to tumor necrosis factor (TNF) antagonist therapies.
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Rheumatoid arthritis (RA) is an autoimmune disorder where the immune system mistakenly attacks the joints, leading to inflammation, pain, and swelling, particularly in the lining of the joints. This often results in symmetrical joint involvement, meaning the same joints on both sides of the body are affected, which distinguishes RA from osteoarthritis.
Baricitinib is a medication used to treat moderate to severe RA. It works by inhibiting Janus kinase (JAK) enzymes, which play a role in the signaling pathways that lead to inflammation. By blocking the release of chemicals that cause pain and swelling, Baricitinib helps to alleviate joint symptoms such as pain, stiffness, and inflammation. It may be prescribed alone or in combination with methotrexate or disease-modifying antirheumatic drugs (DMARDs).
Common side effects include:
- Headache
- Nausea
- Abdominal pain
- Skin rash
- Sore throat
- Diarrhea
If these effects persist or worsen, it's important to consult a healthcare provider.
Always follow your healthcare provider’s instructions and never exceed the prescribed dosage.
It is not recommended to use alcohol with Baricent 4. Please consult your doctor if you have any concerns.
Baricent 4 is not recommended to be used in pregnancy as it may harm your foetus. Consult your doctor before using this medicine.
Baricent 4 is not recommended for use in breastfeeding as it may pass into breast milk and cause irritation to your infant. Consult your doctor before using this medicine.
Baricent 4 does not affect your ability to drive.
Exercise caution before using Baricent 4 in case of established kidney disease. Please consult your doctor to address any concerns.
Exercise caution before using Baricent 4 in case of established liver disease as it may cause a derangement of liver enzymes. Please consult your doctor to address any concerns.
Baricitinib
Rheumatoid Arthritis
Baricent works by blocking the release of certain enzymes (JAK1 and JAK2 enzymes) that increase pain and swelling. Thus, this medicine provides relief from pain and reduces discomfort in your physical movements.
Baricitinib is used in the treatment of rheumatoid arthritis.
Baricitinib is a selective inhibitor of Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2). These enzymes are involved in signaling pathways that regulate immune and inflammatory responses. By inhibiting JAK1 and JAK2, Baricitinib reduces the activation of signal transducers and activators of transcription (STATs), which leads to decreased inflammation and immune activity in rheumatoid arthritis.
In case of overdose, monitor the patient for adverse reactions and provide appropriate treatment if needed.
Store at or below 30°C. Keep away from light and moisture. Keep out of reach of children.
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